Lymph node metastasis of osteosarcomas

Lymph node metastasis of osteosarcomas is a rather rare phenomenon; according to different authors, the incidence of lymph node metastasis is 4 to 11%. The detection of lymph node metastases in osteosarcoma is associated with a significant reduction in the 5-year survival of patients and allows its...

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Bibliographic Details
Published inArkhiv patologii Vol. 78; no. 4; p. 58
Main Author Vasiliev, N V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.2016
Subjects
Bone Neoplasms - epidemiology
Bone Neoplasms - pathology
Epithelial-Mesenchymal Transition
Female
Humans
Lymphatic Metastasis
Male
Osteosarcoma - epidemiology
Osteosarcoma - pathology
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Summary:Lymph node metastasis of osteosarcomas is a rather rare phenomenon; according to different authors, the incidence of lymph node metastasis is 4 to 11%. The detection of lymph node metastases in osteosarcoma is associated with a significant reduction in the 5-year survival of patients and allows its classification as clinical stage IV tumor. The risk factors for lymph node metastases in patients with bone sarcomas are age (≥64 years), gender (female), nosological entity (undifferentiated pleomorphic sarcoma, osteosarcoma, chondrosarcoma), tumor depth (muscle, bone), and the size of primary tumor (>5 сm). The mechanism of lymph node metastasis of osteosarcomas seems to be related to mesenchymal-to-epithelial transition.
ISSN:0004-1955
DOI:10.17116/patol201678458-62