Lymph node metastasis of osteosarcomas
Lymph node metastasis of osteosarcomas is a rather rare phenomenon; according to different authors, the incidence of lymph node metastasis is 4 to 11%. The detection of lymph node metastases in osteosarcoma is associated with a significant reduction in the 5-year survival of patients and allows its...
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Published in | Arkhiv patologii Vol. 78; no. 4; p. 58 |
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Main Author | |
Format | Journal Article |
Language | Russian |
Published |
Russia (Federation)
01.07.2016
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Subjects | |
Online Access | Get more information |
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Summary: | Lymph node metastasis of osteosarcomas is a rather rare phenomenon; according to different authors, the incidence of lymph node metastasis is 4 to 11%. The detection of lymph node metastases in osteosarcoma is associated with a significant reduction in the 5-year survival of patients and allows its classification as clinical stage IV tumor. The risk factors for lymph node metastases in patients with bone sarcomas are age (≥64 years), gender (female), nosological entity (undifferentiated pleomorphic sarcoma, osteosarcoma, chondrosarcoma), tumor depth (muscle, bone), and the size of primary tumor (>5 сm). The mechanism of lymph node metastasis of osteosarcomas seems to be related to mesenchymal-to-epithelial transition. |
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ISSN: | 0004-1955 |
DOI: | 10.17116/patol201678458-62 |