Effect of 1% Metronidazole Rinsing Solution on the Occurrence of Complications after Tooth Extraction: A Clinical Trial Study

• Published in: World Journal of Dentistry Vol. 3; no. 3; pp. 234 - 238
• Main Authors: Badrian, Hamid, Haghighat, Abbas, Khorrami, Behnam, Khalighinajad, Navid, Rajaei, Majid
• Format: Journal Article
• Language: English
• Published: 01.09.2012
• ISSN: 0976-6006; 0976-6014
• DOI: 10.5005/jp-journals-10015-1162

ABSTRACT Introduction Extraction of impacted third molar is a very common operation performed by dentists and oral and maxillofacial surgeons. This surgery is usually done without complications occurring; however, some complications arise from time to time. The aim of this study was to evaluate the effect of 1% metronidazole rinsing solution on the occurrence of complications after extraction of impacted third molars. Materials and methods In this clinical trial study 120 males and females aged 20 to 35 took part, randomly divided into two groups, each including 60 participants. In the case group, mandibular third molar socket was rinsed with 1% metronidazole rinsing solution in duration of the surgery extraction, while normal saline was used for the control group. Afterwards, four common complications—dry socket syndrome, swelling, pain and trismus - were evaluated at 24 hours, 3, 7 and 14 days following the operation. Data were analyzed with Mann-Whitney and t-test using SPSS software version 16. Results Except for pain 24 hours after the operation, none of the differences between the two groups were statistically significant (p ≤ 0.05). Discussion The results of this study show that using 1% metronidazole rinsing solution is not helpful in decreasing the occurrence of complications after extraction of an impacted third molar. It is therefore not recommended to use this solution until advantages are proved to prevent bacterial tolerance. How to cite this article Haghighat A, Khorrami B, Badrian H, Khalighinajad N, Rajaei M. Effect of 1% Metronidazole Rinsing Solution on the Occurrence of Complications after Tooth Extraction: A Clinical Trial Study. World J Dent 2012;3(3): 234-238.