Brain death and changes in solid organ characteristics due to acute lack of female sex hormones

Results Female rats exhibited increased leukocyte infiltration into the lungs and the heart when compared with male rats (p = 0.009 in the lungs and p = 0.022 in the heart) and presented also a sudden decrease in estradiol levels 6 hours after BD (p = 0.01). Conclusion The increased inflammation in...

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Published inCritical care (London, England) Vol. 19; no. S2; p. P50
Main Authors Junior, Roberto Armstrong, B Faloppa, Ana Cristina, Kudo, Guilherme K, P Moreira, Luiz Felipe, Sannomiya, Paulina, Simão, Raif R, Ferreira, Sueli G
Format Journal Article
LanguageEnglish
Published London BioMed Central 01.01.2015
Subjects
Estrogens
Heart
Hormones
Poster Presentation
Rodents
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Summary:Results Female rats exhibited increased leukocyte infiltration into the lungs and the heart when compared with male rats (p = 0.009 in the lungs and p = 0.022 in the heart) and presented also a sudden decrease in estradiol levels 6 hours after BD (p = 0.01). Conclusion The increased inflammation in the lungs and heart of female rats might be a result of the lack of female sex hormones. [...]the idea of introducing a therapeutic use of female sex hormones on female BD donors could be considered.
ISSN:1364-8535
1364-8535
1366-609X
1466-609X
DOI:10.1186/cc14692