Comparison of outcome in patients with cirrhosis and ascites following treatment with albumin or a synthetic colloid

• Published in: Liver international Vol. 26; no. 1; pp. 46 - 54
• Main Authors: Moreau, Richard, Valla, Dominique-Charles, Durand-Zaleski, Isabelle, Bronowicki, Jean-Pierre, Durand, François, Chaput, Jean-Claude, Dadamessi, Innocenti, Silvain, Christine, Bonny, Corinne, Oberti, Frédéric, Gournay, Jérôme, Lebrec, Didier, Grouin, Jean-Marie, Guémas, Eric, Golly, Dominique, Padrazzi, Bruno, Tellier, Zéra
• Format: Journal Article
• Language: English
• Published: Oxford, UK Munksgaard International Publishers 01.02.2006
• Subjects: albumin; ascites; cirrhosis; complications; cost analysis; plasma expander
• ISSN: 1478-3223; 1478-3231
• DOI: 10.1111/j.1478-3231.2005.01188.x

: Background: The question of which colloid (albumin or synthetic colloids) used for plasma expansion following paracentesis or other complications requiring fluid loading in patients with cirrhosis remains controversial. Aims: To compare outcome and hospital‐related cost in patients with cirrhosis treated with 20% human albumin with those treated with a synthetic colloid (3.5% polygeline). Methods: The primary end point was occurrence of a first liver‐related complication. Results: When the trial was prematurely discontinued because of safety concerns about bovine‐derived products, 30 patients were assigned to receive albumin and 38 were assigned to receive a synthetic colloid. Sixty‐three patients were included for ascites removal by paracentesis and five patients for ascites removal by paracentesis and renal impairment. The median time to first liver‐related complication was not significantly longer in the albumin group (20 vs. 7 days). However, the total number of liver‐related complications adjusted to a 100‐day period was significantly lower in the albumin group. The median hospital cost for a 30‐day period was significantly lower in the albumin group (1915 euros vs. 4612 euros). Conclusions: In patients with cirrhosis and ascites, human albumin appears to be more effective in preventing liver‐related complications than synthetic colloid. This may be associated with decreased hospital costs.