0456 Relation between Primary Aldosteronism and Obstructive Sleep Apnea

• Published in: Sleep (New York, N.Y.) Vol. 41; no. suppl_1; p. A173
• Main Authors: Shirahama, R, Mtsuzawa, Y, Kimura, M, Wada, H, Tanigawa, T, Nishikawa, T
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 27.04.2018
• Subjects: Body mass index; Endocrine disorders; Sleep apnea; Urine
• ISSN: 0161-8105; 1550-9109
• DOI: 10.1093/sleep/zsy061.455

Abstract Introduction Both Obstructive sleep apnea (OSA) and Primary aldosteronism (PA) are related to drag resistance hypertension. The main objective of this study is to review the relation between the severity of OSA and clinical parameters of PA. Methods We checked 32 patients (20 male and 12 female) diagnosed as an aldosterone-production adenoma (APA) by ACTH-loaded Adrenal Venous Sampling (AVS) and had one side adrenalectomy. The severity of OSA was checked with Type 3 sleep monitor, and review the association between the severity of OSA and the plasma aldosterone, activity of plasma renin and BNP. Results The average age of the subjects was 52.2 years old, and the average Body mass index (BMI) was 25.8. 46.9% of the subjects were diagnosed as moderate OSA (Respiratory disturbance index (RDI)≧15). Especially 70% of obesity subgroup (BMI≧25) and 20% of normal weight subgroup (BMI<25) were diagnosed as moderate OSA. The aldosterone in the urine indicated positive correlation with AHI by a group of BMI more than 25 (r=0.506, p<0.05), and the longest apnea time was positive correlation with aldosterone/BNP ratio (r=0.517, p<0.05). Conclusion It became clear that OSA is merged with overweight APA patients in a high rate. Increase of aldosterone in the urine reflected the chronic stimulus by aldosterone, and related to the severity of OSA. The body fluid didn’t always reflect BNP, and was suggested that the aldosterone/BNP ratio can be a pathological marker. The changes of aldosterone /BNP ratio was a result of the activated fluctuation of DPP4. In the case of the obesity and high blood pressure with OSA, it is necessary to consider existence of PA. Support (If Any):