Influence of alpha-glutamil-tryptophan on the background and induced activity of factors of adaptive immunity for prevention

• Published in: Acta biomedica scientifica Vol. 8; no. 6; pp. 31 - 40
• Main Authors: Ruleva, A. A., Krasnov, A. A., Petlenko, S. V., Zaplutanov, V. A., Apryatina, V. A.
• Format: Journal Article
• Language: English; Russian
• Published: Scientific Сentre for Family Health and Human Reproduction Problems 14.01.2024
• Subjects: alfa-glutamyl-tryptophan; factors of innate immunity; healthy volunteers; interferon-alpha; non-specific prophylaxis; viral infections
• ISSN: 2541-9420; 2587-9596
• DOI: 10.29413/ABS.2023-8.6.4

Background . During the ongoing COVID-19 pandemic and in the season of rising incidence of other respiratory infections, it is relevant to use preventive measures of  non-specific prophylaxis. Synthetic peptides are widely considered as a tool. The representative of this group is the synthetic analogue of thymus regulatory peptides Thymogen, which has been used in Russia for more than 20 years in the treatment of acute and chronic infection diseases. The aim of the study . To evaluate the effect of Thymogen, a dosed nasal spray, on induced parameters of the immune system during prophylactic use in healthy volunteers. Materials and methods . Twenty healthy volunteers received Thymogen nasal dosed spray (JSC  “Cytomed”, Russia) at a dose of 25  μg twice a day for 10  days. A  comparative assessment of  immunological parameters was carried out in dynamics: before the start of therapy, on days 6 and 11 of taking the drug and 14 days after the end of the course. Clinical observation was carried out from day 1 to day 11, registration of adverse events – the entire period of the study for 24 days. The first day was considered the day the drug was started. Results . In the course of the work, according to the data of immunological examination, a statistically significant increase in the virus-induced production of interferon alpha (INF-α) by a culture of peripheral blood cells was revealed. The growth rate was recorded on day  11 of taking Thymogen and persisted for 14  days after  the  end  of  the  course. Significant differences in the dynamics of bactericidal and phagocytic activity of neutrophils, serum α- and γ-interferon were not obtained. Conclusion . The use of Thymogen spray at a dose of 25 μg for 10 days was safe and contributed to a significant induction of interferon-alpha in response to exposure to a viral pathogen, which allows us to recommend the drug for prophylactic use during the period of rising incidence of acute respiratory diseases.