A Review of MDA-5 Dermatomyositis and Associated Interstitial Lung Disease

Anti-melanoma differentiation-associated gene 5 (MDA-5) dermatomyositis (DM) is noteworthy for its association with rapidly progressive interstitial lung disease (RP-ILD), vasculopathy, and distinctive cutaneous features. First identified in a Japanese cohort in 2005, MDA-5 DM carries a significant...

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Published inRheumato Vol. 4; no. 1; pp. 33 - 48
Main Authors Bhandari, Sambhawana, Zickuhr, Lisa, Baral, Maun Ranjan, Bhalla, Sanjeev, Jones, Heather, Bucelli, Robert, Sen, Deepali
Format Journal Article
LanguageEnglish
Published MDPI AG 28.02.2024
Subjects
MDA-5 antibody
MDA-5 DM
MDA-5 DM ILD
rapidly progressing interstitial lung disease
RP-ILD
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Summary:Anti-melanoma differentiation-associated gene 5 (MDA-5) dermatomyositis (DM) is noteworthy for its association with rapidly progressive interstitial lung disease (RP-ILD), vasculopathy, and distinctive cutaneous features. First identified in a Japanese cohort in 2005, MDA-5 DM carries a significant mortality risk, emphasizing the crucial need for early diagnosis. This review explores the pathogenesis, clinical presentation, diagnosis, management, and prognosis of MDA-5 DM and ILD and includes new research and recommendations regarding disease management.
ISSN:2674-0621
2674-0621
DOI:10.3390/rheumato4010004