18O incorporation in the oxidation of N-methylcarbazole by lignin peroxidase and a model compound: a mechanistic insight into the oxidative N-demethylation of aromatic tertiary amines

Using 18O labelled reactants and/or solvent, the origin of the oxygen in the products of the oxidation of N-methylcarbazole by H2O2 catalysed by lignin peroxidase and a model compound has been determined, so getting important information about the mechanism of the oxidative N-demethylation of aromat...

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Bibliographic Details
Published inChemical communications (Cambridge, England) no. 9; pp. 946 - 947
Main Authors Baciocchi, Enrico, Gerini, Maria Francesca, Lapi, Andrea
Format Journal Article
LanguageEnglish
Published England 07.05.2002
Subjects
Amines - chemistry
Amines - metabolism
Methylation
Oxidation-Reduction
Oxygen Isotopes - pharmacokinetics
Peroxidases - metabolism
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Summary:Using 18O labelled reactants and/or solvent, the origin of the oxygen in the products of the oxidation of N-methylcarbazole by H2O2 catalysed by lignin peroxidase and a model compound has been determined, so getting important information about the mechanism of the oxidative N-demethylation of aromatic tertiary amines.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1359-7345
1364-548X
DOI:10.1039/b201492k