(774) Gender Disparities in the Heart Transplant Implantation: A Nationwide Study from 2009-2020

• Published in: The Journal of heart and lung transplantation Vol. 42; no. 4; pp. S340 - S341
• Main Authors: Faisaluddin, M., Ahmed, A. Zaky, Patel, H., Thakkar, S., Dani, S.S., Alweis, R., Feitell, S.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.04.2023
• ISSN: 1053-2498; 1557-3117
• DOI: 10.1016/j.healun.2023.02.788

Heart transplantation has been established as a procedure of choice in selected group of end stage heart failure patients with proven better survival and quality of life. We sought to study the trends and outcomes in Heart transplantation field in females. Data on patients who receive heart transplant was extracted from the National Inpatient Sample database from 2009 to 2020 using the ICD 10 codes. The study sample was stratified based on sex. Baseline attributes and in-hospital mortality were compared between the two groups. A trend of number of patients over the years was also analysed. 14,552 Patients received heart transplant were identified from 2009 through 2020. Females utilizing LVADs were relatively younger; however, males had significantly higher prevalence of HTN, DM, CAD and history of MI at baseline. Women represented a smaller proportion of heart transplant recipients (28.2%) but their numbers have been increasing through the years (21.9% in 2009 to 25.7% in 2020). Women were at significantly higher risk of cardiac arrest, haemorrhagic stroke and major bleeding (P value <0.0001). Female sex was independently associated with increased post-heart transplant inpatient mortality beyond adjustment for demographics and risk factors (odds ratio, 1.2; 95% CI, 1.117-1.386; P<0.0001). There was a decline in women in-hospital mortality over the years, but increased again in 2014 and 2015 reaching 6% and 6.9% respectively. No woman received a heart transplant in 2020. Despite their small numbers, women receiving heart transplant have higher adjust in-hospital mortality as well as risk of major bleeding, haemorrhagic stroke and cardiac arrest. More research is needed to investigate the gender related difference in hospital outcomes of heart transplant recipients.