Clozapine-induced liver injury and pleural effusion

Clozapine, whilst associated commonly with a transient and benign increase in liver enzymes, has also been associated with varying presentations of hepatitis in existing case reports. This report describes what we believe to be the first documented case of acute liver injury and pleural effusion ass...

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Published inMental illness Vol. 6; no. 2; pp. 36 - 37
Main Authors Kane, Joseph P.M., O'Neill, Francis A.
Format Journal Article
LanguageEnglish
Published Bingley Hindawi Limited 02.09.2014
Subjects
Antipsychotics
Pleural effusion
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Summary:Clozapine, whilst associated commonly with a transient and benign increase in liver enzymes, has also been associated with varying presentations of hepatitis in existing case reports. This report describes what we believe to be the first documented case of acute liver injury and pleural effusion associated with clozapine, resolving after cessation of the agent. The case supports existing literature in advocating a high index of suspicion, particularly in the 4-5 weeks following clozapine initiation, when considering nonspecific clinical symptoms and signs.
ISSN:2036-7465
2036-7465
DOI:10.1108/mi.2014.5403