Formulation and evaluation of fast dissolving buccal patches of tenofovir disoproxil fumarate

• Published in: Research journal of pharmacy and technology Vol. 14; no. 1; pp. 225 - 230
• Main Authors: Reddy, D. Maheswara, Chetty, C. Madhusudhana, Reddy, Y. Dastagiri, Komali, P., Divya, B. Sri, Rani, S. Sandhya
• Format: Journal Article
• Language: English
• Published: Raipur A&V Publications 2021
• Subjects: Antiretroviral drugs; Drug delivery systems; Drug dosages; Hepatitis; Kinetics; Moisture absorption; Pediatrics; Permeability; Pharmaceuticals; Solvents
• ISSN: 0974-3618; 0974-360X; 0974-306X
• DOI: 10.5958/0974-360X.2021.00039.1

[...]conclusion can be made that stable dosage form can be developed for Tenofovir disoproxil fumarate for fast release by buccal patches. [...]both the solutions were mixed and homogenized on the magnetic stirrer for another 1 h. Then the solution was casted into the Petriplates for drying into the oven at 50°C for 24 h. After drying the film was cut into suitable size and stored in aluminum foil in well closed container. [...]different concentrations like 10pg/ml, 20pg/ml, 30pg/ml, 40pgml, and 50pg/ml were prepared. Drug dissolution from pharmaceutical dosage forms that do not disaggregate and release the drug slowly, assuming that the area does not change and no equilibrium conditions are obtained can be represented by the following equation Qt = Q0+KT Where Qt is the amount of drug dissolved in time t, Q0 is the initial amount of drug in the solution and Ko is the zero order release constant. b. First order kinetics: