Thrombotic thrombocytopenic purpura complicating SjÖgren's syndrome with crescentic glomerulonephritis and membranous nephritis

The association of either thrombotic thrombocytopenic purpura (TTP) or crescentic glomerulonephritis with Sjogrens syndrome is rare. We report a case of TTP appearing after the diagnosis of Sjogrens syndrome with crescentic glomerulonephritis and membranous nephropathy. Circulating immune complex wa...

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Bibliographic Details
Published inModern rheumatology Vol. 14; no. 2; p. 174
Main Authors Abe, Haruo, Tsuboi, Norioki, Yukawa, Sonosuke, Tsuji, Souichirou, Hayashi, Haeru, Yukawa, Naoichiro, Takanashi, Hirofumi, Tahara, Koichiro, Tonozuka, Norihiko, Hayashi, Tohru
Format Journal Article
LanguageEnglish
Published Tokyo Informa Healthcare 01.06.2004
Subjects
Autoimmune diseases
Case studies
Circulatory system
Drug therapy
Steroids
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Summary:The association of either thrombotic thrombocytopenic purpura (TTP) or crescentic glomerulonephritis with Sjogrens syndrome is rare. We report a case of TTP appearing after the diagnosis of Sjogrens syndrome with crescentic glomerulonephritis and membranous nephropathy. Circulating immune complex was detected, and immune complex deposits were shown along the capillary walls of renal biopsy specimens. Despite steroid pulse therapy and plasma exchange therapy, the patient died. The etiology of TTP is unclear. This case is important when considering the etiology of TTP related to autoimmune disease. [PUBLICATION ABSTRACT]
ISSN:1439-7595
1439-7609
DOI:10.1007/s10165-004-0287-4