Systemic lupus erythematosus (SLE) presenting with nephrotic syndrome and membranous glomerulopathy in a 10-year-old girl

The authors report the case of a 10‐y‐old girl with clinical diagnosis of systemic lupus erythematosus (SLE), made at the age of 6 y, based upon arthritis, serositis, haematological disorder and positive antinuclear antibody. The first manifestation of disease—Raynaud's phenomenon—appeared at t...

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Published inActa Paediatrica Vol. 94; no. 10; pp. 1507 - 1509
Main Authors Machado, Vânia, Pontes, Teresa, Brito, Iva, Afonso, Caldas
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.10.2005
Subjects
child
intravenous cyclophosphamide
membranous glomerulonephritis
prednisolone
Systemic lupus erythematosus
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Summary:The authors report the case of a 10‐y‐old girl with clinical diagnosis of systemic lupus erythematosus (SLE), made at the age of 6 y, based upon arthritis, serositis, haematological disorder and positive antinuclear antibody. The first manifestation of disease—Raynaud's phenomenon—appeared at the age of 4 y. Seven months after the diagnosis, she developed nephrotic proteinuria with haematuria. Percutaneous renal biopsy showed membranous glomerulonephritis, the least common form of lupus nephritis. Conclusion: Intravenous cyclophosphamide therapy associated with oral prednisolone proved effective in inducing complete remission of nephrotic syndrome.
Bibliography:ArticleID:APA1507
istex:48AD7A3CD7CA55DF4592B79F5C506A5A86FB3F52
ark:/67375/WNG-N9LRZSR3-6
ISSN:0803-5253
1651-2227
DOI:10.1111/j.1651-2227.2005.tb01829.x