Comparative Analysis of Gene Expression Profiles in Ovarian Clear Cell Carcinoma and High-Grade Serous Ovarian Cancer

• Published in: Journal of the College of Physicians and Surgeons--Pakistan Vol. 34; no. 9; pp. 1066 - 1072
• Main Authors: Ye, Chen, Hu, Gang, Zhou, Xiaoni, Deng, Wen, Hu, Kai, Fu, Minglei
• Format: Journal Article
• Language: English
• Published: Pakistan 01.09.2024
• Subjects: Adenocarcinoma, Clear Cell - genetics; Adenocarcinoma, Clear Cell - pathology; Adult; Aged; Biomarkers, Tumor - genetics; China - epidemiology; Cystadenocarcinoma, Serous - genetics; Cystadenocarcinoma, Serous - pathology; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Middle Aged; Ovarian Neoplasms - genetics; Ovarian Neoplasms - pathology; Prognosis; Transcriptome; China
• ISSN: 1022-386X; 1681-7168; 1681-7168
• DOI: 10.29271/jcpsp.2024.09.1066

To evaluate disparities in gene expression profiles between Ovarian Clear Cell Carcinoma (OCCC) and High-Grade Serous Ovarian Carcinoma (HGSOC). A descriptive study. Place and Duration of the Study: The Second People's Hospital of Jingdezhen, Jiangxi, China, between 31st December 2017 and December 2023. Basic and clinical diagnostic information, along with genetic test reports, were compiled from all patients within the included groups. Differential gene expression between the two cohorts was scrutinised to elucidate its clinical significance. Comparative analysis revealed nine differentially expressed genes in OCCC relative to HGSOC, with six exhibiting significant disparities (p <0.05). These genes are implicated in pivotal cellular processes including the cell cycle, apoptosis, DNA damage repair, and the PI3K pathway. Notably, aberrant expression patterns, such as overexpression of MET and downregulation of PTEN and SMARCA4, correlated with adverse prognosis and survival outcomes in selected patients. Distinctive gene expression profiles between OCCC and HGSOC underscore disparate tumorigenic mechanisms, thereby laying a foundation for the tailored therapeutic interventions. Further elucidation of the identified differentially expressed genes is warranted to delineate their role in OCCC pathogenesis and prognostic significance. Ovarian clear cell carcinoma, High-grade serous ovarian cancer, Gene expression profiles, Homologous recombination repair.