Synthesis and characterization of new 2-amino-4-(substituted phenyl)-6-(7’’-methoxy, 3’’,4’’-dihydro, 2’’,2’’-dimethyl-2hbenzopyran) pyrimidines and their bio evaluation

A series of eight novel 2-amino-4-(substituted phenyl)-6-(7"- methoxy, 3",4"-dihydro, 2",2"-dimethyl-2H-benzopyran) pyrimidines were designed and synthesized by utilizing benzene-1,3-diol as starting material. The structures of the isolated products (6a-h) were established t...

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Bibliographic Details
Published inJournal of the Serbian Chemical Society Vol. 77; no. 7; pp. 859 - 866
Main Authors Murthy, Y.L.N., Suhasini, Padma, Anjali, Jha
Format Journal Article
LanguageEnglish
Published Serbian Chemical Society 2012
Subjects
2-amino pyrimidine derivatives
antimicrobial activity
benzopyran
chalcones
claisen-schmidt condensation
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Summary:A series of eight novel 2-amino-4-(substituted phenyl)-6-(7"- methoxy, 3",4"-dihydro, 2",2"-dimethyl-2H-benzopyran) pyrimidines were designed and synthesized by utilizing benzene-1,3-diol as starting material. The structures of the isolated products (6a-h) were established through 1HNMR, 13C-NMR, and FT-IR spectroscopic techniques and elemental analysis. The synthesized compounds were utilized for screening antimicrobial properties against gram positive (Bacillus pumilus, Bacillus subtilis, Streptococcus faecalis), gram negative bacteria (Enterococcus faecalis, Escheria coli, Proteus vulgaris) and fungi (Pencillian expasom, Aspergillus niger, Candida albicans) using Ampicillin and Ketoconazole. Most of the compounds showed moderate to high antibacterial and antifungal activities against studied strains with inhibition zones between 8 and 30 mm. nema
ISSN:0352-5139
1820-7421
DOI:10.2298/JSC110923008M