Tuberculosis-immune reconstitution inflammatory syndrome in an immunocompetent patient

Tuberculosis-immune reconstitution inflammatory syndrome is commonly seen among patients with acquired immunodeficiency syndrome either as a paradoxical worsening of an already diagnosed disease or as an uncovering of a dormant infection. There is evidence of paradoxical worsening of central nervous...

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Published inAsian Journal of Internal Medicine Vol. 2; no. 2; pp. 53 - 56
Main Authors Janya, J., Amarasingha, A., Jayawardene, H., Dissanayake, D. M. K. P., Mihiranga, E. A. D., Jayanaga, W. W. L. A.
Format Journal Article
LanguageEnglish
Published Sri Lanka College of Internal Medicine 08.08.2023
Subjects
Central nervous system tuberculosis
Tuberculosis-immune reconstitution inflammatory syndrome
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Summary:Tuberculosis-immune reconstitution inflammatory syndrome is commonly seen among patients with acquired immunodeficiency syndrome either as a paradoxical worsening of an already diagnosed disease or as an uncovering of a dormant infection. There is evidence of paradoxical worsening of central nervous system tuberculosis (CNS-TB) once the treatment is instituted even among immunocompetent patients leading to significant morbidity. We report a case of a previously well young woman with paradoxical worsening of CNS-TB after commencement of treatment. This case highlights an important possible clinical sequelae of CNS-TB, a practicing physician should be aware of.
ISSN:2827-7260
DOI:10.4038/ajim.v2i2.109