Acute Postdialysis Changes in Plasma ICAM-1 and IL-1 Levels in Hemodialysis Patients

• Published in: Hemodialysis international Vol. 7; no. 1; pp. 73 - 104
• Main Authors: EL-Hefeni, S, Moghazy, T, Ragab, M, Khalil, E
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.02.2003
• ISSN: 1492-7535; 1542-4758
• DOI: 10.1046/j.1492-7535.2003.01259.x

Fifty subjects: 20 controls and 30 hemodialysis patients were included in the study. The acute changes in plasma ICAM‐1 and IL‐1β levels immediately after dialysis were evaluated using two types of membranes and two types of dialysate. The predialysis ICAM‐1 level in the whole patients was significantly higher than controls, while that of IL‐1β was significantly lower. The postdialysis ICAM‐1 showed insignificant higher level than the predialysis one, while that of IL‐1β showed significant higher level than both the predialysis and control levels. Both postdialysis ICAM‐1 and IL‐1β levels in patients using cuprophane membrane (bioincompatible) showed insignificant higher levels than in those using polysulfone one (biocompatible). The percent increase in ICAM‐1 level did not significantly differ in these two subgroups, while the percent increase in IL‐1β level showed significantly higher value in those using bioincompatible membrane (108%) than that in those using biocompatible membrane (44%). No significant difference in the levels of either ICAM‐1 or IL‐1β were found between patients using acetate and bicarbonate dialysate. Conclusion: the bioincompatibility of the membrane is the important factor in the occurrence of the acute reaction during hemodialysis.