Bioactivity Study of Thiophene and Pyrazole Containing Heterocycles

Chalcones3a-fwere prepared by reacting thiophene containing pyrazolyl aldehyde (2) with different 2-hydroxy acetophenones 1a-f. The compounds3a-f were transformed into different Pyrazolines 4a-f. The formation of chromene derivatives 5a-f occurred from the cyclization of 3a-f, which were then transf...

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Bibliographic Details
Published inOriental journal of chemistry Vol. 37; no. 4; pp. 891 - 899
Main Authors Kale, Nitin V, Salve, Supriya P., Karale, Bhausaheb K., Mhaske, Sadhana D., Dare, Sushama B.
Format Journal Article
LanguageEnglish
Published Bhopal Oriental Scientific Publishing Company 30.08.2021
Subjects
Aldehydes
Biological activity
E coli
Enzymes
Fungicides
Pharmaceutical sciences
Pyrazole
Salmonella
Synthesis
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Summary:Chalcones3a-fwere prepared by reacting thiophene containing pyrazolyl aldehyde (2) with different 2-hydroxy acetophenones 1a-f. The compounds3a-f were transformed into different Pyrazolines 4a-f. The formation of chromene derivatives 5a-f occurred from the cyclization of 3a-f, which were then transformed into pyrazole derivatives 6a-f. Newly synthesized compounds have promising antibacterial activity against S.typhii and S.aureus, while weak activity against B.subtilis and E.coli. Compounds 5d and 6d had significant antifungal action towardsA. niger, while most of the compounds were moderately active towards T.viride. Some of the synthesized compounds showed promising α-amylase inhibitory activity at 1 mg/mL concentration.
ISSN:0970-020X
2231-5039
DOI:10.13005/ojc/370417