l ‐Proline‐functionalized Fe 3 O 4 nanoparticles as a novel magnetic chiral catalyst for the direct asymmetric Mannich reaction

l ‐Proline has been successfully anchored on the surface of magnetic nanoparticles and characterized using powder X‐ray diffraction, scanning electron microscopy, vibrating sample magnetometry and Fourier transform infrared spectroscopy. These nanoparticles as a chiral catalyst have been employed to...

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Bibliographic Details
Published inApplied organometallic chemistry Vol. 29; no. 8; pp. 566 - 571
Main Authors Safaei‐Ghomi, Javad, Zahedi, Safura
Format Journal Article
LanguageEnglish
Published 01.08.2015
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Summary:l ‐Proline has been successfully anchored on the surface of magnetic nanoparticles and characterized using powder X‐ray diffraction, scanning electron microscopy, vibrating sample magnetometry and Fourier transform infrared spectroscopy. These nanoparticles as a chiral catalyst have been employed to promote the direct asymmetric Mannich reaction. The corresponding products are obtained in high yields with high level of diastereoselectivity (up to 99:1 dr) in the presence of Fe 3 O 4 – l ‐proline. Also this heterogeneous catalyst can be recovered easily and reused many times without significant loss of its catalytic activity. Copyright © 2015 John Wiley & Sons, Ltd.
ISSN:0268-2605
1099-0739
DOI:10.1002/aoc.3333