Visible-light-mediated metal-free decarboxylative acylation of electron-deficient quinolines using α-ketoacids under ambient air

A visible-light-promoted metal-free decarboxylative coupling protocol for the acylation of electron-deficient quinolines using ambient air as an oxidant has been disclosed. This environmental-friendly protocol takes place under mild conditions and is highlighted by using inexpensive photocatalyst an...

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Bibliographic Details
Published inTetrahedron Vol. 112; p. 132749
Main Authors Zheng, Zhongqi, Wu, Yongdi, Lu, Xuelian, Zhang, Fang-Lin, Qi, Mei-Fang, Sun, Enjie, Sun, Bing
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 23.04.2022
Subjects
Acylation
Decarboxylative coupling
Heterocycles
Metal-free
Visible-light
Heterocycles
Decarboxylative coupling
Metal-free
Visible-light
Acylation
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Summary:A visible-light-promoted metal-free decarboxylative coupling protocol for the acylation of electron-deficient quinolines using ambient air as an oxidant has been disclosed. This environmental-friendly protocol takes place under mild conditions and is highlighted by using inexpensive photocatalyst and starting materials, thereby integrating C–H functionalization and recent photoredox scenario based on diaryl ketones. This work contributes to a more systematic utilization of α-ketoacids as an efficient source of acyl radicals in acylation of electron-deficient heteroaromatic compounds. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2022.132749