2D AMESING multi-echo 31P-MRSI of the liver at 7T allows transverse relaxation assessment and T2-weighted averaging for improved SNR
Liver diseases are a major global health concern often requiring invasive assessment by needle biopsy. 31P magnetic resonance spectroscopic imaging (MRSI) allows non-invasive probing of important liver metabolites. Recently, the adiabatic multi-echo spectroscopic imaging sequence with spherical k-sp...
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Published in | Magnetic resonance imaging Vol. 34; no. 2; pp. 219 - 226 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Inc
01.02.2016
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Subjects | |
Online Access | Get full text |
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Summary: | Liver diseases are a major global health concern often requiring invasive assessment by needle biopsy. 31P magnetic resonance spectroscopic imaging (MRSI) allows non-invasive probing of important liver metabolites. Recently, the adiabatic multi-echo spectroscopic imaging sequence with spherical k-space sampling (AMESING) was introduced at 7T, enabling acquisition of T2 information. T2-weighed averaging of the multiple echoes improves signal-to-noise ratio (SNR). The purpose of our study was to implement AMESING MRSI of the liver at 3T and 7T, derive localized T2 information and compare T2-weighted average spectra in terms of SNR.
Ten male volunteers underwent 2D AMESING MRSI at 3T and 7T after a minimum four-hour fast. SNR was calculated for PC, PE, Pi, GPE, GPC and α-ATP using maximum peak amplitudes and the SD of the noise. Metabolite peak ratios were calculated after fitting in jMRUI. SNR values and peak ratios were compared with the Wilcoxon signed-rank test.
For the first time liver metabolites' T2 values at 7T were measured: PE (55.6±3.5ms), PC (51.2±2.3ms), Pi (46.4±1.1ms), GPE (44.0±0.8ms), GPC (50.4±0.8ms) and α-ATP (18.2±0.4ms). SNR gain using T2-weighted averaging at 7T resulted in a 1.2× SNR gain. In conjunction with higher field strength and improved coil set-up T2-weighted averaging at 7T allowed a total 3.2× SNR gain compared to 3T FID-only.
AMESING 2D MRSI of the liver at 7T provides T2 values that allow T2-weighted averaging of data from multiple echoes resulting in improved SNR. |
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ISSN: | 0730-725X 1873-5894 |
DOI: | 10.1016/j.mri.2015.10.018 |