RETRACTED: 3-Benzhydryl-4-piperidones as novel neurokinin-1 receptor antagonists and their efficient synthesis

• Published in: Bioorganic & medicinal chemistry Vol. 19; no. 17; pp. 5175 - 5182
• Main Authors: Shirai, Junya, Nakamura, Minoru, Tarui, Naoki, Hashimoto, Tadatoshi, Ikeura, Yoshinori
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.09.2011
• ISSN: 0968-0896; 1464-3391
• DOI: 10.1016/j.bmc.2011.07.014

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the authors. Subsequent to publication, it became clear to the authorship group that there was a serious mistake about the origin of the lead compound. The manuscript indicated that the lead compound was found from high-throughput screening of our chemical library. However, it was revealed that the lead compound had been originally designed and synthesized aiming to get the biological activities by one of the authors. Furthermore, Dr. Yukimasa was omitted as an author, while in fact Dr. Yukimasa led the drug discovery research toward the hit compound. The authors concluded that these facts made the paper inappropriate and unfaithful, and therefore made the decision to retract.