Telomerase activity in human gastric and colorectal cancer and surrounding tissues

R73; Objective: To study the telomerase activities in human gastric and colorectal tumors. Methods: The telomerase activity was assayed by the telomeric repeat amplification protocol (TRAP) technique. Forty human tumor samples including 9 colonic, 20 rectal and 11gastric carcinomas and their surroun...

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Published inChinese journal of cancer research Vol. 11; no. 1; pp. 13 - 15
Main Authors Chen, Wen, Zhang, Qiao, Wan, De-sen, Cun, Ling-yun, Wu, Cheng-qiu, Pan, Zhi-zhong
Format Journal Article
LanguageEnglish
Published Department of Health Toxicology, School of Public Health,Sun Yat-Sen University of Medical Sciences, Guangzhou 510089, China%Department of Surgery, Cancer Center,Sun Yat-Sen University of Medical Sciences, Guangzhou 510089, China 01.03.1999
Subjects
Colonic neoplasms
Rectal neoplasms
Telomerase
Stomach neoplasms
Tumor biomarkers
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Summary:R73; Objective: To study the telomerase activities in human gastric and colorectal tumors. Methods: The telomerase activity was assayed by the telomeric repeat amplification protocol (TRAP) technique. Forty human tumor samples including 9 colonic, 20 rectal and 11gastric carcinomas and their surrounding tissues were used for the detection. Results: Thirty-six out of 40human tumor samples exhibited telomerase activity regardless of the stages or the differentiation of the tumors. However, only 1 out of 39 tumor surrounding tissues showed telomerase activity. Conclusion: Telomerase may be a good diagnosis biomarker for tumor detection.
ISSN:1000-9604
1993-0631
DOI:10.1007/s11670-999-0095-7