De-novo donor-specific antibody (DSA) against HLA-DQ antigens resulting in acute antibody mediated rejection in a renal transplant patient

A highly sensitive single antigen bead assay (SAB) by luminex is a very useful tool for post-transplant monitoring of HLA antibodies for diagnosing antibody-mediated rejection ABMR. Donor-specific anti-HLA antibodies that arise de-novo (de-novo DSA) after transplantation, indicate the highest risk f...

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Bibliographic Details
Published inClinical queries, nephrology (India) Vol. 5; no. 1; pp. 1 - 3
Main Authors Mehrotra, Sonia, Sharma, Raj K., Prasad, Narayan, Gupta, Amit, Bhadauria, Dharmendra S., Kaul, Anupama
Format Journal Article
LanguageEnglish
Published Elsevier India Pvt Ltd 01.01.2016
Subjects
Anti DQ DSA
C4d negative ABMR
Lysate crossmatch
SAB
C4d negative ABMR
SAB
Lysate crossmatch
Anti DQ DSA
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Summary:A highly sensitive single antigen bead assay (SAB) by luminex is a very useful tool for post-transplant monitoring of HLA antibodies for diagnosing antibody-mediated rejection ABMR. Donor-specific anti-HLA antibodies that arise de-novo (de-novo DSA) after transplantation, indicate the highest risk for acute antibody-mediated rejection (AMR) and graft loss. The return of pre-existing antibodies after transplantation or the development of new de-novo anti-HLA or non-HLA DSA may also confer an increased risk for graft loss. A case with de-novo donor-specific antibody (DSA) against HLA-DQ antigens resulting in acute antibody-mediated rejection (ABMR) in a renal transplant patient is presented along with review of literature.
ISSN:2211-9477
2211-9477
DOI:10.1016/j.cqn.2016.04.002