Synthesis and 1H, 13C and 15N NMR characterisation of substituted Pyrazolo[4,3-c]quinolines and related compounds

A wide range of novel and known alkyl substituted pyrazolo[4,3-c]quinolines and related compounds were synthesized. Some of these compounds can undergo tautomerism and differences have been noted in the structural assignments already published. For each of these compounds, a complete assignment was...

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Bibliographic Details
Published inTetrahedron Vol. 74; no. 22; pp. 2797 - 2806
Main Authors Black, Shannon L., O'Connor, Patrick D., Boyd, Maruta, Blaser, Adrian, Kendall, Jackie D.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 31.05.2018
Subjects
13C NMR
15N NMR
1H NMR
1H-13C HMBC
1H-15N HMBC
NMR
Pyrazolo[4,3-c]quinolines
15N NMR
NMR
1H NMR
Pyrazolo[4,3-c]quinolines
1H-15N HMBC
13C NMR
1H-13C HMBC
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Summary:A wide range of novel and known alkyl substituted pyrazolo[4,3-c]quinolines and related compounds were synthesized. Some of these compounds can undergo tautomerism and differences have been noted in the structural assignments already published. For each of these compounds, a complete assignment was made using 1H, 13C and 15N one- and two-dimensional NMR measurements, including NOESY, COSY, 1H-13C HSQC and 1H-13C HMBC. 1H-15N HMBC NMR has proved crucial in determining the relevant tautomeric and protonated state of the compounds. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2018.04.061