Clinicopathological study on primary malignant melanoma of the oral mucosa Part I: Histological features of our nine cases

Malignant melanoma of the skin is now classified into four major types: 1) lentigo maligna melanoma (LMM), 2) superficial spreading melanoma (SSM), 3) nodular melanoma (NM), 4) acral lentiginous melanoma (ALM). However, classification of melanoma of the oral mucous membrane has not yet been well-doc...

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Published inJapanese Journal of Oral and Maxillofacial Surgery Vol. 33; no. 10; pp. 1991 - 1999
Main Authors UMEDA, Masahiro, TERANOBU, Osamu, TANAKURA, Yoshimasa, ISHIDA, Hisao, FUJITA, Kunio, NAKANISHI, Koichi, SHIMADA, Keikichi
Format Journal Article
LanguageEnglish
Published Japanese Society of Oral and Maxillofacial Surgeons 20.10.1987
Subjects
histological feature
malignant melanoma
oral mucosa
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Summary:Malignant melanoma of the skin is now classified into four major types: 1) lentigo maligna melanoma (LMM), 2) superficial spreading melanoma (SSM), 3) nodular melanoma (NM), 4) acral lentiginous melanoma (ALM). However, classification of melanoma of the oral mucous membrane has not yet been well-documented. We discussed clinico-pathologically our nine oral melanoma cases and the following findings were obtained. 1. Eight of nine cases showed three lesion phases clinically; a nodular lesion (A-phase), a plaque lesion (B-phase), and a macular lesion (C-phase). 2. Histological examination revealed spindle or epithelioid tumor cells in A-phase, pre-invading tumor cell nests resembling pagetoid tumor nests in B-phase, proliferation of dendritic melanocytes or simple hyperpigmentation along the basal cell layer in C-phase. 3. According to the above findings, eight cases were interpreted as ALM, while one case lacking for B-and C-phase was considered as NM.
ISSN:0021-5163
2186-1579
DOI:10.5794/jjoms.33.1991