Availability of sentinel node as predictive index of lymph node metastases to early-stage gastric cancer surgery

• Published in: Journal of Clinical Oncology Vol. 29; no. 4_suppl; p. 10
• Main Authors: Kamiya, S., Takeuchi, H., Niihara, M., Kaburagi, T., Nakamura, R., Oyama, T., Takahashi, T., Wada, N., Saikawa, Y., Kitagawa, Y.
• Format: Journal Article
• Language: English; Japanese
• Published: American Society of Clinical Oncology (ASCO) 01.02.2011
• ISSN: 0732-183X; 1527-7755
• DOI: 10.1200/jco.2011.29.4_suppl.10

Abstract only 10 Background: Recently, the less invasive surgery for the early gastric cancer attract considerable attention, in particular, sentinel node navigation surgery (SNNS) is expected to be a new strategy. We analyzed the feasibility of sentinel node (SN) biopsy and its accuracy in predicting the lymph node status in patients with early gastric cancer. Methods: Between 1999 and 2009, we have performed the gastrectomy with SN biopsy during an operation in over 500 cases. We focused attention on 115 patients with cT1N0, less or equal 40 mm in size, and isolated gastric cancer and they had undergone the individualized minimizing gastrectomy. Proximal, pylorus-preserving gastrectomy and wedge resections were performed in 51, 54 and 10 patients, respectively. We used a dual procedure with dye- and gamma probe-guided techniques for SN mapping and resected SN and non-SN as was conventionally done for the safety. Results: Subjects were 85 males and 30 females with a mean age of 63.4 years. 53 patients had undergone laparoscopy-assisted gastrectomy. The mean number of SNs was 4.3/case. Of the four patients were SN positive and false-negative was found in one case. The sensitivity of detecting metastases was 80.0% (4/5) and the accuracy was 99.1% (114/115). One case had a recurrence in the liver and no cases without SN metastasis were confirmed any recurrences and metastases. Conclusions: This study showed the diagnostic accuracy of metastasis based on SN was very high, and the minimized resection and lymphadenectomy could be performed safely. No significant financial relationships to disclose.