Putative Integrative Mobile Elements That Exploit the Xer Recombination Machinery Carrying bla IMI -Type Carbapenemase Genes in Enterobacter cloacae Complex Isolates in Singapore

Whole-genome sequencing was performed on 16 isolates of the carbapenemase-producing complex to determine the flanking regions of -type genes. Phylogenetic analysis of multilocus sequence typing (MLST) targets separated the isolates into 4 clusters. The -type genes were all found on Xer-dependent int...

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Published inAntimicrobial agents and chemotherapy Vol. 62; no. 1
Main Authors Koh, Tse H, Rahman, Nurdyana Binte Abdul, Teo, Jeanette W P, La, My-Van, Periaswamy, Balamurugan, Chen, Swaine L
Format Journal Article
LanguageEnglish
Published United States 01.01.2018
Subjects
antimicrobial resistance
mobile genetic elements
carbapenemase
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Summary:Whole-genome sequencing was performed on 16 isolates of the carbapenemase-producing complex to determine the flanking regions of -type genes. Phylogenetic analysis of multilocus sequence typing (MLST) targets separated the isolates into 4 clusters. The -type genes were all found on Xer-dependent integrative mobile elements (IMEX). The IMEX elements of 5 isolates were similar to those described in Canada, while the remainder were novel. Five isolates had IMEX elements lacking a resolvase and recombinase.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01542-17