Studies on coagulation and fibrinolysis with liver cirrhosis and primary liver carcinoma

• Published in: Blood & Vessel Vol. 8; no. 1; pp. 111 - 115
• Main Authors: OIKAWA, Iwao, TAMAKI, Akira, SAITO, Isao, IKEDA, Eiichi, KASAI, Yoichi
• Format: Journal Article
• Language: English
• Published: The Japanese Society on Thrombosis and Hemostasis 01.01.1977
• Subjects: Antithrombin-III; Cirrhosis; Hepaplastintest; Primary liver carcinoma; Prothrombin time
• ISSN: 0386-9717; 1884-2372
• DOI: 10.2491/jjsth1970.8.111

Coagulation and fibrinolytic system in cirrhosis, hepatoma with cirrhosis and hepatoma without cirrhosis was studied. The cases of liver cirrhosis showed the decrease of coagulant factors and anti-coagulant factors, hyperactivity of plasminogen and plasmin system and the decrease of protease inhibitors. Those results suggested strongly the degree of the liver damage. In the cases of hepatoma with cirrhosis, abnormalities were observed more strongly than the hepatoma without other changes on the coagulation and fibrinolytic findings but hepatoma with cirrhosis had less abnormalities than liver cirrhosis alone. And the values of the complement-III in the hepatoma with cirrhosis were showed the normal upper range. Those results demonstrated that no abnormal activations of the complement III were acted on those states. From the reason of those results in the hepatoma with cirrhosis, the progressions of the cirrhosis and the refusal reaction to hepatoma were thoght to be not so remarkable.