Antibacterial and Biofilm-Preventive Photocatalytic Activity and Mechanisms on P/F-Modified TiO 2 Coatings

• Published in: ACS applied bio materials Vol. 3; no. 9; pp. 5687 - 5698
• Main Authors: Yan, Yige, Soraru, Charline, Keller, Valérie, Keller, Nicolas, Ploux, Lydie
• Format: Journal Article
• Language: English
• Published: United States ACS Publications 21.09.2020
• Subjects: Bioengineering; Biomaterials; Chemical Sciences; Life Sciences; Material chemistry; mechanism; antibacterial P/F-modified TiO2 coating; photocatalytic activity; immediate versus long-term biofilm-preventive activity; surface topographic properties; Antibacterial P/F-modified TiO2 coating
• ISSN: 2576-6422; 2576-6422
• DOI: 10.1021/acsabm.0c00467

Photocatalytic antibacterial and biofilm-preventive activity in liquid of heavy-metal-free coatings based on a phosphorus (P)- and fluorine (F)-modified TiO photocatalyst has been investigated. They reveal significantly higher immediate and longer-term (biofilm-preventive) inactivation capacity than a reference coating made of the commercial photocatalyst TiO P25 on three bacterial species differing in cell wall type and ability to resist oxidative stress ( , , ) (up to more than 99% reduction of colonization on P/F-modified TiO coating compared to about 50% on P25 TiO coating for 10 min UV-A illumination). This results from the P- and F-induced improvement of photocatalyst properties and from the smoother surface topography, which shortens reactive oxygen species (ROS) diffusion to the outer membrane of the targeted adhered bacteria. Decrease in ROS-related impairment of cell wall, respiratory, and enzymatic activities confirms the loss of ROS throughout the bacterial cell degradation. and are less sensitive than , with a probable relation to the bacterial oxygen stress defense mechanism. The coating antibacterial efficacy was highly affected by phosphate ions and the richness in dissolved oxygen of the reaction medium.