Effects of sodium benzoate on the complications of 1. 5% glycine solution using two different intravesical pressures during bladder irrigation

• Published in: Acta anaesthesiologica Scandinavica Vol. 48; no. 4; pp. 438 - 442
• Main Authors: Yagmurdur, H., Ceyhan, A., Dagli, G., Yuksel, U., Altunatmaz, K., Ide, T., Unal, N.
• Format: Journal Article
• Language: English
• Published: Oxford, UK; Malden , USA Blackwell Publishing Ltd/Inc 01.04.2004
• Subjects: Glycine; sodium benzoate; transurethral prostate resection; urea cycle
• ISSN: 0001-5172; 1399-6576
• DOI: 10.1111/j.1399-6576.2004.00349.x

Background:  In this experimental study we researched the effects of sodium benzoate on the complications of 1.5% glycine solution using with two different intravesical pressures during bladder irrigation. Methods:  Thirty‐six male adult New Zealand rabbits with body weight ranging from 1500 to 2800 g were used in the experiments. The rabbits were randomly allocated to four groups. In groups 1 and 2, 500 ml of 1.5% gylcine was used as irrigating fluid during 30 min, but only group 2 received 500 mg kg−1 of sodium benzoate treatment by oral route immediately after irrigation. In groups 3 and 4, 500 ml of 1.5% glycine was used as irrigating fluid during 60 min, but only group 4 received the same treatment as group 2. Ammonia, urea, sodium, potassium, hemoglobin, hemotocrit and platelet levels were studied at preirrigation and postirrigation on the 4 h and 24 h. Also electrocardiographic (ECG) changes were monitored at the same time with blood parameters. Results:  At 4 h postirrigation, Na+ levels were decreased significantly in group 1 and non‐significantly in group 3 when compared with preirrigation levels. But these levels were not changed in groups 2 and 4. Both at 4 h and 24 h, ammonia and urea levels were significantly increased in groups 1 and 3. Ammonia level was decreased but the urea level was not changed in groups 2 and 4 at the same time points. K+ level was significantly changed only in group 1 at 4 h and 24 h. Hemoglobin and hemotocrit concentrations were decreased both at 4 h and 24 h compared with preirrigation levels in all groups. Also there were ECG changes between the treated and untreated groups. Conclusion:  Sodium benzoate was very effective against the complications of 1.5% glycine during bladder irrigation experimentally. But this needs further investigation, especially for the applicability of this new treatment model in human TURP syndrome.