Laboratory Diagnosis and Potential Application of Nucleic Acid Biosensor Approach for Early Detection of Dengue Virus Infections

Dengue fever is caused by the dengue virus, the genus of Flaviviridae virus family. Until now, there is no specific medication to kill the dengue virus and patients just solely depend on the treatment of the dengue infection symptoms. Thus, a highly sensitive and rapid diagnostic tool for early diag...

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Bibliographic Details
Published inBiosciences, biotechnology research Asia Vol. 15; no. 2; pp. 245 - 255
Main Authors Izuan Abdul Rashid, Jahwarhar, Azah Yusof, Nor
Format Journal Article
LanguageEnglish
Published Bhopal Biosciences Biotechnology Research Asia 28.06.2018
Subjects
Antigens
Biosensors
Cell culture
Chromatography
Commercialization
Dengue fever
Deoxyribonucleic acid
Diagnosis
Diagnostic software
Diagnostic systems
Diagnostic tests
DNA
Enzymes
Fever
Gene amplification
Glycoproteins
Immunization
Infections
Laboratories
Materials science
Mosquitoes
Nucleic acids
Patients
Plasma
Polymerase chain reaction
Sensors
Serology
Tropical diseases
Vaccines
Viral diseases
Viruses
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Summary:Dengue fever is caused by the dengue virus, the genus of Flaviviridae virus family. Until now, there is no specific medication to kill the dengue virus and patients just solely depend on the treatment of the dengue infection symptoms. Thus, a highly sensitive and rapid diagnostic tool for early diagnosis of dengue virus is very desirable, especially in resource limited-condition. We briefly review pro and cons of existing diagnostic methods for the detection of dengue virus (virus isolation, PCR, NS1Ag, Serology). We also highlight the recent advances of the biosensor technology in the dengue diagnostic dengue as a promising point-of-care diagnostic in the future. The DNA based biosensor technology combined miniaturized sample preparation offers a good opportunity for the commercialized point of care testing for dengue diagnosis in the future.
ISSN:0973-1245
2456-2602
DOI:10.13005/bbra/2628