Evaluation of Important Drug Interaction A Comparative Study of Drug Interaction Evaluations between Japan and the United States

Our hospital receives many drug interaction reports from all over the world. But many physicians tend to overlook many drug interactions. In order to provide appropriate drug therapy, we examined the Japanese Pharmaceutical Reference (JPR) to evaluate drug interactions for approximately 2000 medicin...

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Bibliographic Details
Published inIryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) Vol. 28; no. 3; pp. 285 - 293
Main Authors Nakagawa, Michihiko, Hoshikawa, Katsumi, Hukuhara, Yuuko, Katsuta, Hideo, Mizuno, Keiji
Format Journal Article
LanguageJapanese
English
Published Japanese Society of Pharmaceutical Health Care and Sciences 10.06.2002
Subjects
contraindication
drug interaction
Drug Interaction Facts
Japanese Pharmaceutical Reference
Significance 1
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Summary:Our hospital receives many drug interaction reports from all over the world. But many physicians tend to overlook many drug interactions. In order to provide appropriate drug therapy, we examined the Japanese Pharmaceutical Reference (JPR) to evaluate drug interactions for approximately 2000 medicines, which are used at our hospital. We compared our evaluations with those found in the Physicians Desk Reference (PDR) and the Drug Interaction Fact (DIF), which are both American references. We thus found 76 incompatible drug combinations located in the JPR, while there are 80 drug combinations found in the DIF. 16 drug combinations are classified similarly between the JPR and the DIF. In addition, the PDR classifies 6 drug categories with incompatible drug combinations among the 8 drug categories found in the JPR and DIF. Our study concludes that differences exist between Japan and America concerning drug interaction evaluations.
ISSN:1346-342X
1882-1499
DOI:10.5649/jjphcs.28.285