Long-term outcomes of acute coronary syndrome in young adults: Findings from Gulf RACE-2

• Published in: Journal Of The Saudi Heart Association Vol. 24; no. 4; p. 291
• Main Authors: Al-Mohammadi, M., Hersi, A., Alhabib, K.F., Alsheikh-Ali, A.A., Sulaiman, K., Alfaleh, H., Alsaif, S., Almahmeed, W., Asaad, N., Amin, H., Al-Motarreb, A., Al Suwaidi, J.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.10.2012
• ISSN: 1016-7315; 2212-5043
• DOI: 10.1016/j.jsha.2012.06.244

Long term outcome of young patients presenting with acute coronary syndrome (ACS) has not been described in the Middle East. To evaluate the risk factors, presentations, clinical assessments and long term outcome of young patients as compared with older patients with acute coronary syndrome. The multi-center, prospective Arabian Gulf Registry of Acute Coronary Events (Gulf RACE-2) was used to determine the long term outcome of young patients with ACS. Sixty-five hospitals in 6 Arabian Gulf countries enrolled 7930 ACS patients from October 2008 to June 2009. Patients were divided in to two groups. Group A ⩽40years, 686 pts (8.7%) with mean age of 36±4years and Group B >40years, 7244 pts (91.3%). Group A had a higher prevalence of STEMI (62% vs. 42.9%; P<0.001), male gender (91.3% vs. 77.6%; P<0.001), smoking (61.5% vs. 33.2%; P<0.001) and a lower prevalence of diabetes (18% vs. 42.2%; P<0.001), hypertension (21.4% vs. 50.2%; P<0.001) and hyperlipidemia (22% vs. 38.9%; P<0.001) as compared to Group B. However, in-hospital, 30days and 1-year mortality rate were significantly lower in Group A compared with Group B (1.9% vs. 4.8%, 4.4% vs. 8.5% and 5.7% vs. 13.2%, respectively; P<0.001 for all comparisons). ACS among young adults is a major concern. There is a need for prevention programs to control smoking epidemic by targeting young adults in the population. Our study documented for the first time long term outcome among young patients with ACS in the Middle East.