Effect of reboxetine on activity of carboxypeptidase E in the nerve tissue of rats

• Published in: Biomeditsinskaia khimiia Vol. 61; no. 5; p. 657
• Main Authors: Kruchinina, A D, Gengin, M T
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.09.2015
• Subjects: Adrenal Glands - drug effects; Adrenal Glands - enzymology; Amygdala - drug effects; Amygdala - enzymology; Animals; Animals, Outbred Strains; Antidepressive Agents - pharmacology; Carboxypeptidase H - antagonists & inhibitors; Carboxypeptidase H - metabolism; Corpus Striatum - drug effects; Corpus Striatum - enzymology; Hippocampus - drug effects; Hippocampus - enzymology; Hypothalamus - drug effects; Hypothalamus - enzymology; Male; Medulla Oblongata - drug effects; Medulla Oblongata - enzymology; Morpholines - pharmacology; Pituitary Gland - drug effects; Pituitary Gland - enzymology; Rats; Tectum Mesencephali - drug effects; Tectum Mesencephali - enzymology; carboxypeptidase E; depression; regulatory peptides; nerve tissue; monoamines; reboxetine
• ISSN: 2310-6972
• DOI: 10.18097/PBMC20156105657

Depression is one of the most common mental disorders, but its etiology is not completely understood. It is assumed that peptidergic system components are involved in the formation of this pathology. Neuropeptides play an important role in the regulation of mental and emotional states. Сarboxypeptidase E is a key enzyme of peptide processing; it regulates neuropeptide levels in the various structures of the nervous system. We have studied effects of a single dose of reboxetine on the activity of carboxypeptidase E in various brain regions and the adrenal glands of rats. The reboxetine injection decreased carboxypeptidase E activity in the pituitary gland (12 h after injection), in the pituitary gland, the quadrigeminal bodies, the medulla oblongata, the hypothalamus, the hippocampus and the amygdala (24 h after injection), in the pituitary gland and striatum (72 h after injection). The enzyme activity in adrenal glands remained basically unchanged. Apparently, the decrease of carboxypeptidase E activity may influence the level of regulatory peptides involved in the pathogenesis of depression.