Induction chemo-radiotherapy for non-small cell lung cancer invading the chest wall neighboring the vertebral body

Non-small cell lung cancer invading the chest wall neighboring the vertebral body is difficult to completely resect because of its anatomical character. We evaluated the results of induction chemo-radiotherapy aiming to achieve the complete resection of cancer tissue. This regimen was carried out in...

Full description

Saved in:
Bibliographic Details
Published inNihon Kokyuki Geka Gakkai zasshi (Kyoto, 1992) Vol. 21; no. 7; pp. 866 - 870
Main Authors Umezu, Hideo, Sawabata, Noriyoshi, Araki, Osamu, Karube, Yoko, Seki, Norio, Tamura, Motohiko, Kobayashi, Satoru, Ishihama, Hiromi, Nagai, Sensuke, Miyoshi, Shinichiro
Format Journal Article
LanguageJapanese
English
Published The Japanese Association for Chest Surgery 15.11.2007
Subjects
induction chemo-radiotherapy
lung cancer
neighboring the vertebral body
Online AccessGet full text

Cover

More Information
Summary:Non-small cell lung cancer invading the chest wall neighboring the vertebral body is difficult to completely resect because of its anatomical character. We evaluated the results of induction chemo-radiotherapy aiming to achieve the complete resection of cancer tissue. This regimen was carried out in 6 men with a median age of 57 years old. The clinical stage was IIB in 3 cases and IIIA in 3 cases, and the pathological diagnosis was adenocarcinoma in 3 cases and squamous cell carcinoma in 3 cases. Chemotherapy varied, with CDDP+TXT in 3 cases and CDDP+NVR in 3 cases, accompanied by radiotherapy of 40 Gy in 5 cases and 60 Gy in 1 case. Induction treatment was completely carried out in all cases, resulting in stable disease in 4 cases and partial response in 2 cases, followed by complete resection. The pathological efficacy was Ef0 in 1 case, Ef1 in 1 case, Ef2 in 3 cases, and Ef3 in 1 case. Recurrence occurred in 5 cases: 2 marginal recurrences (limited to cases of Ef0 or Ef1), 1 local recurrence (lung), and 2 distant metastases. The median survival time was 19 months and the 3-year survival rate was 22%, with a median follow-up period of 30 months. There is no statistical supporting, but this regimen may effectively reduce the risk of marginal recurrence in cases showing a good pathological response, while extended resection should be an option in cases exhibiting a poor pathological response.
ISSN:0919-0945
1881-4158
DOI:10.2995/jacsurg.21.866