Experimental Inclusion Conjunctivitis in Man

Summary The serum antibody response of volunteers experimentally infected with either of two inclusion conjunctivitis strains (IC Cal 3 or IC Cal 8) was studied by the complement fixation (C′F) and indirect fluorescent antibody (IFA) methods. In most sera both the C′F and IFA titers increased in par...

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Published inThe Journal of immunology (1950) Vol. 101; no. 6; pp. 1154 - 1158
Main Authors Isa, Abdallah M., Hanna, Lavelle, Linscott, William D., Jawetz, Ernest
Format Journal Article
LanguageEnglish
Published 01.12.1968
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Summary:Summary The serum antibody response of volunteers experimentally infected with either of two inclusion conjunctivitis strains (IC Cal 3 or IC Cal 8) was studied by the complement fixation (C′F) and indirect fluorescent antibody (IFA) methods. In most sera both the C′F and IFA titers increased in parallel and reached a maximum level 4 to 6 weeks after infection. The C′F- and IFA-reactive antibodies were confined primarily to the IgG class of immunoglobulin. Low levels of IFA-reactive antibodies were detectable in some IgA fractions, but no antibody activity was detected by either the C′F or the IFA method in the IgM fractions of sera as early as 13 days and as late as 2 years after infection.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.101.6.1154