Changes in exercise tolerance and resting haemodynamics during long-term treatment of heart failure with xamoterol

The long-term efficacy of xamoterol in improving effort capacity and haemodynamics was investigated in a study lasting 1 year in heart failure patients. Following a 3 month, double-blind period of treatment with xamoterol, patients continued therapy for a further 9 months. Exercise duration rose by...

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Bibliographic Details
Published inEuropean heart journal Vol. 11 Suppl A; p. 52
Main Authors Kayanakis, J G, Courtault, L, Fauvel, J M, Boundhoure, J P, Snow, H M
Format Journal Article
LanguageEnglish
Published England 01.04.1990
Subjects
Aged
Cardiac Output, Low - drug therapy
Cardiac Output, Low - physiopathology
Female
Hemodynamics - drug effects
Humans
Male
Middle Aged
Multicenter Studies as Topic
Physical Exertion - drug effects
Propanolamines - pharmacology
Propanolamines - therapeutic use
Xamoterol
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Summary:The long-term efficacy of xamoterol in improving effort capacity and haemodynamics was investigated in a study lasting 1 year in heart failure patients. Following a 3 month, double-blind period of treatment with xamoterol, patients continued therapy for a further 9 months. Exercise duration rose by 27% at 3 months and this improvement was maintained at 12 months. Similarly, the statistically significant increase in cardiac index and reduction in pulmonary wedge pressure and exercise heart rate persisted for 12 months.
ISSN:0195-668X
DOI:10.1093/eurheartj/11.suppl_A.52