Usefulness of quantitative HBsAg in outcome prediction of acute hepatitis B

We evaluated the usefulness of quantitative evaluation of HBsAg in outcome prediction among 133 patients with acute hepatitis B (AH-B). Patients were classified into 4 groups according to duration of HBsAg positivity as follows: less than 3 months (Group I); less than 6 months (Group II); over 6 mon...

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Published inKanzo Vol. 52; no. 6; pp. 380 - 382
Main Authors Takahashi, Hideaki, Okuse, Chiaki, Yotsuyanagi, Hiroshi, Yamada, Norie, Yasuda, Kiyomi, Nagase, Yoshihiko, Suzuki, Michihiro, Koike, Kazuhiko, Itoh, Fumio
Format Journal Article
LanguageJapanese
Published The Japan Society of Hepatology 2011
Subjects
acute hepatitis B
chronicity
quantitative HBsAg
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Summary:We evaluated the usefulness of quantitative evaluation of HBsAg in outcome prediction among 133 patients with acute hepatitis B (AH-B). Patients were classified into 4 groups according to duration of HBsAg positivity as follows: less than 3 months (Group I); less than 6 months (Group II); over 6 months (Group III); and over 12 months (Group IV). An abrupt decrease in HBsAg levels was observed and HBsAg levels at 2 weeks were significantly lower than those at the initial visit in Group I (p<0.001). On the other hand, levels of HBsAg remained high at 4 weeks and 8 weeks in Groups III and IV. Furthermore, HBsAg levels showed an increase from 2 weeks to 4 weeks in Group IV. These results suggest that quantitation of HBsAg at 4 or 8 weeks after initial visit may be useful in the prediction of clinical outcome in AH-B.
ISSN:0451-4203
1881-3593
DOI:10.2957/kanzo.52.380