Prostate Cancer Cellular Uptake of Ternary Titanate Nanotubes/CuFe 2 O 4 /Zn-Fe Mixed Metal Oxides Nanocomposite

Certainly, there is a demand for stronger recognition of how nanoparticles can move through the cell membrane. Prostate cancer is one of the forcing sources of cancer-relevant deaths among men. The current research studied the power of prostate cancer cells to uptake a ternary nanocomposite TNT/CuFe...

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Bibliographic Details
Published inInternational journal of nanomedicine Vol. 15; pp. 619 - 631
Main Authors El-Shahawy, Ahmed Ag, Abdel Moaty, S A, Zaki, A H, Mohamed, Nada A, GadelHak, Yasser, Mahmoud, R K, Farghali, A A
Format Journal Article
LanguageEnglish
Published New Zealand 2020
Subjects
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacokinetics
Cell Line, Tumor
Cell Survival
Copper - chemistry
Dynamic Light Scattering
Humans
Iron - chemistry
Male
Microscopy, Electron, Transmission
Nanocomposites - administration & dosage
Nanocomposites - chemistry
Nanotubes - chemistry
Oxides - chemistry
Photoelectron Spectroscopy
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - pathology
Titanium - chemistry
X-Ray Diffraction
Zinc - chemistry
prostate cancer
cytotoxicity
inorganic nanomaterials
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Summary:Certainly, there is a demand for stronger recognition of how nanoparticles can move through the cell membrane. Prostate cancer is one of the forcing sources of cancer-relevant deaths among men. The current research studied the power of prostate cancer cells to uptake a ternary nanocomposite TNT/CuFe O /Zn-Fe mixed metal oxides (MMO). The nanocomposite was synthesized by a chemical method and characterized by a High-resolution transmission electron microscope, Field emission scanning electron microscope, X-ray diffraction, Fourier transmission infra-red, X-ray photoelectron spectroscopy, dynamic light scattering. Besides, it was implemented as an inorganic anticancer agent versus Prostate cancer PC-3 cells. The results revealed cellular uptake validity, cell viability reduction, ultra-structures alterations, morphological changes and membrane damage of PC-3 cells. The prepared ternary nanocomposite was highly uptake by PC-3 cells and possessed cytotoxicity that was dose and time-dependent. To conclude, the study offered the potential of the investigated ternary nanocomposite as a promising prostate anticancer agent.
ISSN:1178-2013
1178-2013
DOI:10.2147/IJN.S228279