Late metastasis in bilateral familial retinoblastoma and review of literature

A 5-year-old female with bilateral familial retinoblastoma (Group A, Group C) was treated with systemic chemotherapy and three cycles of intra-arterial chemotherapy. She was being followed closely and had no evidence of intraocular recurrence for 4 years. She developed isolated femoral metastasis 5...

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Published inIndian Journal of Ophthalmology Case Reports Vol. 4; no. 1; pp. 235 - 238
Main Authors DeCesare, Thomas, Tiwari, Nishant, Williams, James, Ramasubramanian, Aparna
Format Journal Article
LanguageEnglish
Published Medknow Publications and Media Pvt. Ltd 01.01.2024
Subjects
Cancer
Chemotherapy
Genetic aspects
Metastasis
Retinoblastoma
Stem cells
Transplantation
Vincristine
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Summary:A 5-year-old female with bilateral familial retinoblastoma (Group A, Group C) was treated with systemic chemotherapy and three cycles of intra-arterial chemotherapy. She was being followed closely and had no evidence of intraocular recurrence for 4 years. She developed isolated femoral metastasis 5 years after initial diagnosis and was treated with high-dose chemotherapy and stem cell transplant. This case emphasizes the need for metastatic monitoring for low-grade retinoblastoma and points toward delayed tumor latency.
ISSN:2772-3070
2772-3089
DOI:10.4103/IJO.IJO_1834_23