Follicular Lymphoma With Leukemic Phase: Case Report

Follicular lymphoma (FL) originating from germinal center В cells constitutes 35% of all non-Hodgkin lymphomas. Patients usually present with asymptomatic peripheral lymphadenopathy (LAP) at the time of diagnosis and approximately 70% of them have bone marrow involvement. Leukemic phase of FL is a r...

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Bibliographic Details
Published inEastern journal of medicine Vol. 29; no. 2; pp. 259 - 261
Main Authors Dikici, Hatice Zeynep, Kars, Taha Ulutan, Demircioǧlu, Sinan, Tekinalp, Atakan, Çeneli, Özcan
Format Journal Article
LanguageEnglish
Published Van YYU Tip Fakultesi 2024
Subjects
Asymptomatic
Biopsy
Bone marrow
Case reports
Chemotherapy
Leukemia
Lymphatic system
Lymphoma
Medical prognosis
Patients
Remission (Medicine)
Ankara Turkey
Turkey
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Summary:Follicular lymphoma (FL) originating from germinal center В cells constitutes 35% of all non-Hodgkin lymphomas. Patients usually present with asymptomatic peripheral lymphadenopathy (LAP) at the time of diagnosis and approximately 70% of them have bone marrow involvement. Leukemic phase of FL is a rare condition and associated with a poor prognosis. In this report we presented a 29-year-old male patient with a diagnosis of leukemic phase of FL which is a rare condition. We initiated R-CHOP chemotherapy and he is still being followed in complete remission after 6 course. Leukemic phase is a rare clinical presentation of FL and it can be confused with chronic lymphocytic leukemia. Flowcytometric examination is very valuable in diagnosis. Leukemic phase of FL is associated with poor prognosis independent of FLIPI score. Therefore detecting circulating leukemic cells in patients with FL is necessary.
ISSN:1301-0883
1309-3886
DOI:10.5505/ejm.2024.90023