Fluorine-containing polyamphiphiles of block structure constructed of synthetic and biopolymer blocks
Aim. Purposeful preparation of polymeric surfactants combining hydrophobic fluorine-containing and hydrophilic synthetic and natural blocks via radical and non-radical reactions using peroxide, epoxide and/or amino- terminal groups of the polymeric elementary blocks. Methods. Radical and non-radical...
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Published in | Biopolimery i kletka Vol. 34; no. 3; pp. 207 - 217 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Kiev
Natsional'na Akademiya Nauk Ukrainy - National Academy of Sciences of Ukraine
30.06.2018
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Subjects | |
Online Access | Get full text |
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Summary: | Aim. Purposeful preparation of polymeric surfactants combining hydrophobic fluorine-containing and hydrophilic synthetic and natural blocks via radical and non-radical reactions using peroxide, epoxide and/or amino- terminal groups of the polymeric elementary blocks. Methods. Radical and non-radical condensation reactions, polymerization, spectral (NMR- and luminescence spectroscopy), gel-permeation chromatography and other analytical techniques`. Results. Primary oligomers poly(F-MA)-MP were synthesized via radical polymerization of fluorine-alkyl methacrylate (F-MA) in the presence of peroxide-containing telogen (MP). That provides controlling the oligomer chain length and architectures as well as entering a terminal peroxide group in the macromolecules. Radical polymerization of vinyl pyrrolidone (NVP) initiated by poly(F-MA)-MP as macroinitiator in the presence of epoxide-containing derivative of cumene (CGE) was used for obtaining water soluble poly(F-MA)-block-poly(NVP)-CGE. Finally oligonucleotide (ONC) was attached via condensation reaction of ONC primary amino group with terminal epoxide group of poly(F-MA)-block-poly(NVP)-CGE. Conclusions. A series of novel block/comb-like copolymers with synthetic and natural parts was synthesized. Obtained tri-block copolymers can be used as markers for labeling bacteria and pathological items including cancer cells. |
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ISSN: | 0233-7657 1993-6842 |
DOI: | 10.7124/bc.00097B |