A Brief Communication REDUCED ABSORPTION OF PARACETAMOL FOLLOWING CIMETIDINE IN HEALTHY VOLUNTEERS

Cimetidine has not been shown to affect the pharmacokinetics of paracetamol. However, when the protocol was modified in such a way that paracetamol was taken 1 h after cimetidine, there was a significant effect on its absorption. The C and K (absorption constant) were significantly reduced ( p <...

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Bibliographic Details
Published inToxic substance mechanisms Vol. 16; no. 3; pp. 217 - 220
Main Author M. Garba, A. Mustapha, M. T. Bakare and I. Abdu Aguye
Format Journal Article
LanguageEnglish
Published Informa UK Ltd 01.07.1997
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Summary:Cimetidine has not been shown to affect the pharmacokinetics of paracetamol. However, when the protocol was modified in such a way that paracetamol was taken 1 h after cimetidine, there was a significant effect on its absorption. The C and K (absorption constant) were significantly reduced ( p < .001 for the max difference between the two cases-control and treated). Lag time was greatly increased ( p <.001). This indicates that the therapeutic efficacy of paracetamol may be affected.
ISSN:1076-9188
1091-7659
DOI:10.1080/107691897229586