A Brief Communication REDUCED ABSORPTION OF PARACETAMOL FOLLOWING CIMETIDINE IN HEALTHY VOLUNTEERS
Cimetidine has not been shown to affect the pharmacokinetics of paracetamol. However, when the protocol was modified in such a way that paracetamol was taken 1 h after cimetidine, there was a significant effect on its absorption. The C and K (absorption constant) were significantly reduced ( p <...
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Published in | Toxic substance mechanisms Vol. 16; no. 3; pp. 217 - 220 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
Informa UK Ltd
01.07.1997
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Online Access | Get full text |
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Summary: | Cimetidine has not been shown to affect the pharmacokinetics of paracetamol. However, when the protocol was modified in such a way that paracetamol was taken 1 h after cimetidine, there was a significant effect on its absorption. The C and K (absorption constant) were significantly reduced ( p < .001 for the max difference between the two cases-control and treated). Lag time was greatly increased ( p <.001). This indicates that the therapeutic efficacy of paracetamol may be affected. |
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ISSN: | 1076-9188 1091-7659 |
DOI: | 10.1080/107691897229586 |