Chromosome 2q33 genetic polymorphisms in Tunisian endemic pemphigus foliaceus
Abstract Background Several studies have suggested that polymorphisms within genes encoding T‐lymphocyte immune regulating molecules: CD28 , CTLA ‐ 4 , and ICOS , may alter the signaling process and subsequently could be involved in susceptibility to a broad spectrum of autoimmune diseases. Methods...
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Published in | Molecular genetics & genomic medicine Vol. 8; no. 11 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Bognor Regis
John Wiley & Sons, Inc
01.11.2020
|
Subjects | |
Online Access | Get full text |
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Summary: | Abstract
Background
Several studies have suggested that polymorphisms within genes encoding T‐lymphocyte immune regulating molecules:
CD28
,
CTLA
‐
4
, and
ICOS
, may alter the signaling process and subsequently could be involved in susceptibility to a broad spectrum of autoimmune diseases.
Methods
This study aimed to replicate associations between common polymorphisms in the 2q33.2 cluster and susceptibility to pemphigus foliaceus (PF) in the Tunisian population. We investigated seven polymorphisms: rs3116496 and rs1879877 (
CD28
), rs231775, rs3087243, and (AT)
n
repeat (
CTLA4
); rs11889031 and rs10932029 (
ICOS
) in a case–control study which enrolled 106 Tunisian PF patients and 205 matched healthy controls.
Results
We confirmed the associations with
CTLA4
((AT)
13
,
p
= 0.00137, OR = 3.96 and (AT)
20
,
p
= 0.008, OR = 5.22; respectively) and
ICOS
genes (rs10932029>CT,
p
= 0.034, OR = 2.12 and rs10932029>TT,
p
= 0.04 and OR = 0.41).
Conclusion
Our results indicate that susceptibility to PF is located in the proximal and the distal 3′ flanking region of the
CTLA4
/
ICOS
promoter. These findings may open avenues to the treatment of patients with biological drugs targeting CTLA4/ICOS molecules, in a personalized manner to achieve more effective treatment. |
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ISSN: | 2324-9269 2324-9269 |
DOI: | 10.1002/mgg3.1476 |