Extragenic Suppression analysis of TS mutations using Sec61p
Abstract During synthesis, secretory and membrane proteins are cotranslationally translocated into the lumen of the endoplasmic reticulum through an aqueous gated channel. Proper folding, degradation, and transport of many polypeptides depend on a diverse set of helper proteins termed chaperone. I h...
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| Published in | Nature precedings |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
08.08.2007
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| Online Access | Get full text |
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| Summary: | Abstract
During synthesis, secretory and membrane proteins are cotranslationally translocated into the lumen of the endoplasmic reticulum through an aqueous gated channel. Proper folding, degradation, and transport of many polypeptides depend on a diverse set of helper proteins termed chaperone. I hypothesize thatSec 61p is a membrane chaperone, which actively directs membrane protein folding. |
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| ISSN: | 1756-0357 1756-0357 |
| DOI: | 10.1038/npre.2007.651.1 |