Synthesis and antitumor activity of novel pyrazolo[1,5-a]pyrimidine derivatives

A novel series of pyrazolo[1,5-a]pyrimidine-3-carbonitriles substituted with 7-amino, 7-substituted amino and 5-substituted amino groups was synthesized. Some of the newly synthesized compounds were tested in vitro on human colon tumor cell line (HCT116). Compound 14a displayed the highest activity...

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Published inEuropean journal of chemistry Vol. 2; no. 3; pp. 331 - 336
Main Authors El-Enany, Mervat Mostafa, Kamel, Mona Monir, Khalil, Omneya Mahmoud, El-Nassan, Hala Bakr
Format Journal Article
LanguageEnglish
Published 30.09.2011
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Summary:A novel series of pyrazolo[1,5-a]pyrimidine-3-carbonitriles substituted with 7-amino, 7-substituted amino and 5-substituted amino groups was synthesized. Some of the newly synthesized compounds were tested in vitro on human colon tumor cell line (HCT116). Compound 14a displayed the highest activity among the tested compounds with IC sub(50) that equals to 0.0020 mu M.
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ISSN:2153-2249
2153-2257
DOI:10.5155/eurjchem.2.3.331-336.319