Assessment of Subgingival Biofilm and its Relationship with the Status of Tumors in a Population with Breast Cancer

• Published in: International journal of odontostomatology Vol. 17; no. 4; pp. 511 - 522
• Main Authors: Gomes, Maria da Conceição Machado, Ribeiro-Júnior, Roberto Silva, Pimenta, Tatiana Massariol, Martins, Bárbara da Silva, Rodrigues, Mayara, Aguilar, Waniara, Santos, Diandra Zipinotti, Figueiredo, Magda Feres, Lopes, Guilherme da Rocha Scalzer, Matos, Jefferson David Melo de, Bottino, Marco Antonio, Feitosa, Alfredo, Rangel, Leticia Batista Azevedo
• Format: Journal Article
• Language: English; Portuguese
• Published: Universidad de La Frontera. Facultad de Medicina 01.12.2023
• Subjects: DENTISTRY, ORAL SURGERY & MEDICINE; microbiota subgingival; breast tumors; dental research; investigación dental; DNA-DNA hybridization; subgingival microbiota; enfermedad periodontal; tumores de mama; hibridación ADN-ADN; periodontal disease
• ISSN: 0718-381X; 0718-381X
• DOI: 10.4067/S0718-381X2023000400511

This study aimed to compare the subgingival microbiota of subjects with and without breast cancer (BC). Patients with BC (Group 1; n= 50) and without BC (Group 2; n=50) with periodontitis (A) and without periodontitis (B). The study was conducted in two phases (P1 and P2). One biofilm sample was collected from each subject and analyzed by DNA-DNA Hybridization (Checkerboard DNA-DNA). The relative abundance of the subgingival microbiota differed between the Case and Control groups. However, some species were higher in patients in the Case than in Control subjects and differed between the groups in both phases. Composition of the subgingival microbial community according to the Socransky complex was related to periodontal disease, followed by clinical attachment of level (CAL ≥4mm), age, and tooth loss, which were found to be abundant in Cases when compared with controls. Patients with Tumor Grade II and III had a higher prevalence of tooth loss and CAL≥4mm. It was concluded that in individuals with BC, the sub-gingival microbiota exhibited atypical changes, but they developed periodontal disease.