P03-08 Metabolism of Enniatin B in primary mouse, rat and human hepatocytes

Enniatins produced by Fusarium species belong to emerging mycotoxins commonly found in cereals and raising concern for food and feed. They are potentially toxic to humans and therefore represent a public health issue. However, due to the lack of toxicokinetic and toxicodynamic data that could be use...

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Bibliographic Details
Published inToxicology letters Vol. 399; p. S125
Main Authors Dubreil, E., Ivanova, L., Gendre, C., Mahdjoub, M., Fessard, V., Le Hégarat, L., Faeste, C., Henri, J.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.09.2024
Elsevier
Subjects
Life Sciences
Toxicology
toxicity
sécurité alimentaire
hepatocyte
test in vivo
toxicocinétique
hépatocyte
toxicologie
enniantin
céréale
santé publique
toxicodynamic
toxicité
Fusarium
human
humain
public health
cytotoxicity
in-vitro test
microsomes
toxicology
rat
enniantine
test in vitro
in-vivo test
cytotoxicité
food safety
mycotoxin
toxicodynamique
cereal
toxicokinetic
mycotoxine
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Summary:Enniatins produced by Fusarium species belong to emerging mycotoxins commonly found in cereals and raising concern for food and feed. They are potentially toxic to humans and therefore represent a public health issue. However, due to the lack of toxicokinetic and toxicodynamic data that could be used to derive a Health-Based Guidance Value, enniatins are not regulated at the European level [1].
ISSN:0378-4274
1879-3169
DOI:10.1016/j.toxlet.2024.07.322