Synthesis and Biological Evaluation of 6-Substituted Mangiferin Derivatives as Antioxidant and Anti-cancer Agents

Esterified and alkyl amine derivatives of mangiferin were synthesized and evaluated for in vitro antioxidant and anticancer activities. The chemical structures of the derivatives were confirmed using elemental analysis and spectral data. The antioxidant activity was assessed using a 2,2-diphenyl-1-p...

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Bibliographic Details
Published inLetters in organic chemistry Vol. 19; no. 6; pp. 477 - 483
Main Authors Patil, Mohan H., Kabra, Uma D., Gupta, Krishna R., Umekar, Milind J.
Format Journal Article
LanguageEnglish
Published SHARJAH Bentham Science Publ Ltd 01.06.2022
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
synthesis
1
antioxidant
3
DPPH
7-trihydroxyxanthone
Mangiferin derivatives
MTT
anticancer
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Summary:Esterified and alkyl amine derivatives of mangiferin were synthesized and evaluated for in vitro antioxidant and anticancer activities. The chemical structures of the derivatives were confirmed using elemental analysis and spectral data. The antioxidant activity was assessed using a 2,2-diphenyl-1-picrylhydrazy (DPHH) assay, and some derivatives displayed antioxidant activity better than mangiferin and standard drug ascorbic acid. Among the synthesized derivatives, few exhibited more enhanced anticancer activity against human breast (MDA-MB-231) cancer cell lines than the parent mangiferin.
ISSN:1570-1786
1875-6255
DOI:10.2174/1570178618666210813123545